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STRENGTHEN YOUR SINUS SURGERY ARMAMENTARIUM WITH THE PROPEL FAMILY OF IMPLANTS

The PROPEL family of implants offers 3 steroid-eluting implants under one brand, allowing ENTs to select the best option that conforms to the anatomical needs of their patients1-3

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MAXILLARY
SINUS

FRONTAL
SINUS

ETHMOID
SINUS

For ethmoid sinus1

For ethmoid sinus and
frontal sinus recess2

For sinus ostia:
frontal and maxillary3

Learn more about the benefits of PROPEL implants after sinus surgery

ARM YOURSELF WITH THE PROPEL FAMILY OF IMPLANTS, AN INNOVATION IN SINUS TECHNOLOGY

PROPEL is the FIRST and ONLY PMA-approved steroid-eluting sinus implant4

OPENS + DELIVERS

PROPEL keeps the sinuses open while releasing MF

PROPEL implants feature an innovative 2-in-1 mechanism that opens the sinuses while delivering mometasone furoate (MF), a potent corticosteroid, directly where it is needed1-3

+OPENS the sinus cavity

  • Self-expanding design that opens and supports the sinus cavity1

  • Non-obstructive design allows for sinus mucociliary clearance and the delivery of topical rinses1

  • Dissolvable frame bio-absorbs over 30-45 days after placement as the sinus cavity heals

+DELIVERS MF locally

  • Delivers 370 μg of MF over 30 days

  • MF present in the sinus mucosal tissue for up to 60 days5

Mometasone furoate delivers the ideal combination of potency and safety

Drug characteristics comparison6-9
Topical
Corticosteroid
Lipophilicity6* Potency7†
(Receptor Affinity)
Systemic
Bioavailability8‡
Dexamethasone Very Low (<1.0)9 Very Low (100) High (76%)
Triamcinolone (Kenalog) Low (1.0) Low (233) Medium (46%)
Budesonide Low (1.6) Intermediate (935) Medium (34%)
Mometasone furoate High (20.0) High (2300) Very Low (<1%)

*Lipophilicity numbers normalized relative to triamcinolone acetonide.

As measured by relative receptor binding affinity compared to dexamethasone, which is set to a value of 100. Higher values designate greater potency.

As measured by plasma concentration of drug from intranasal vs. intravenous route.

Mometasone furoate was selected for use in PROPEL implants for its optimal sinonasal drug characteristics10:

Highly lipophilic
Readily absorbs into tissue

Targeted and potent
High glucocorticoid receptor affinity

Low systemic bioavailability
Minimizes systemic effects

PROPEL implants are clinically proven to maintain patency and improve patient outcomes following ESS by targeting inflammation, the underlying cause of chronic rhinosinusitis

YOUR PATIENT
+
PROPEL
=
IMPROVED
OUTCOMES

GET PROPEL

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This site is intended for healthcare professionals in the United States

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References

  1. PROPEL [Instructions for Use]. Menlo Park, CA: Intersect ENT; 2013.
  2. PROPEL Mini [Instructions for Use]. Menlo Park, CA: Intersect ENT; 2016.
  3. PROPEL Contour [Instructions for Use]. Menlo Park, CA: Intersect ENT; 2016.
  4. Food and Drug Administration. Approval Order. https://www.accessdata.fda.gov/cdrh_docs/pdf10/P100044S018A.pdf. Accessed June 28, 2019.
  5. Li PM, Downie D, Hwang PH. Controlled steroid delivery via bioabsorbable stent: safety and performance in a rabbit model. Am J Rhinol Allergy. 2009;23(6):591-596.
  6. Lemke T, Williams D, Roche V, Zito SW, eds. Foye’s Principles of Medicinal Chemistry. 6th ed. Balitmore, MD: Lippincott Williams & Wilkins; 2008.
  7. Winkler J, Hochhaus G, Derendorf H. How the lung handles drugs: pharmacokinetics and pharmacodynamics of inhaled corticosteroids. Proc Am Thorac Soc. 2004;1(4):356-363.
  8. Sastre J, Mosges R. Local and systemic safety of intranasal corticosteroids. J Investig Allergol Clin Immunol. 2012;22(1):1-12.
  9. PubChem. Dexamethasone. https://pubchem.ncbi.nlm.nih.gov/compound/Dexamethasone. Accessed June 28, 2019.
  10. Hochhaus G. Pharmacokinetic/pharmacodynamic profile ofmometasone furoate nasal spray: potential effects on clinical safety and efficacy. Clin Ther. 2008;30(1):1-13.